Global HFO Refrigerant Market to Reach $6.27 Billion by 2025, Growing at 18.2% CAGR

Global HFO refrigerant market was valued at $6,267 million in 2025 and is growing at a CAGR of 18.2% during the forecast period (2026-2035). The HVACR industry is undergoing a structural transition toward low-global warming potential (GWP) refrigerants, driven by the need to reduce environmental impact while maintaining system performance across comfort cooling, commercial refrigeration, and transport refrigeration applications. This shift has accelerated the adoption of hydrofluoroolefin (HFO)-based refrigerants, which offer a balance of lower emissions, energy efficiency, and compatibility with existing equipment.

Browse the full report description of “HFO Refrigerant Market Size, Share & Trends Analysis Report by Refrigerant Type (R-1234Yf, R-1234Ze, R-1234Zd) by Application (Refrigeration, and Air-Conditioning) By End-User (Domestic, Commercial, Transportation, Industrial, and Others) Forecast Period (2026-2035)” at https://www.omrglobal.com/industry-reports/hfo-refrigerant-market

As a result, refrigerant suppliers are expanding their portfolios to address replacement demand created by the gradual phase-down of high-GWP refrigerants and to support both new installations and retrofit markets. For instance, in May 2025, Arkema enhanced its range of lower global warming potential (GWP) refrigerant solutions through a partnership with Honeywell International Inc. This expansion aims to meet the increasing demand for HFO blends in the HVACR industry and facilitate the HFC phasedown. The newly offered refrigerants under Arkema’s Forane brand include such as Forane 454B (R-454B) with a GWP of 466, suitable for comfort cooling; Forane 448A (R-448A) and Forane 449A (R-449A) as replacements for R-404A and R-507A in commercial refrigeration; Forane 452A (R-452A) for transport refrigeration; and Forane 513A (R-513A), which reduces GWP by over 50% compared to R-134A, suitable for various refrigeration and air conditioning applications. These refrigerants comply with industry regulations and improve energy efficiency for users.

Key Innovators Driving HFO Refrigerant Transformation

The key players in the HFO refrigerant market include DuPont Inc., Daikin Industries, Ltd., Honeywell International Inc., The Chemours Co., A-Gas International Ltd., among others. These companies are driving innovation in digital health solutions such as telemedicine, electronic health records, remote patient monitoring, and AI-powered clinical tools, shaping the future of healthcare delivery globally.

• In May 2022, Honeywell introduced Solstice 456A, a new HFO-based refrigerant aimed at the European automotive aftermarket, capable of reducing greenhouse gas emissions from air conditioning systems in existing vehicles by over 50%. This economical, drop-in solution is compatible with vehicles manufactured before 2017 and performs similarly to R-134A, meeting the demands of vehicle owners and auto repair shops amid new EU climate legislation. Solstice 456A will be available later this year. Honeywell has invested significantly in research and development for this technology, anticipating the need for lower-GWP solutions to combat climate change, offering products that enhance energy efficiency without compromising performance across various applications.

Market Coverage

• The market number available for – 2025-2035
• Base year- 2025
• Forecast period- 2026-2035
• Segment Covered-
  • By Refrigerant Type
  • By Application
  • By End-User
• Regions Covered-
  • North America
  • Europe
  • Asia-Pacific
  • Rest of the World
• Competitive Landscape - DuPont Inc., Daikin Industries, Ltd., Honeywell International Inc., The Chemours Co., A-Gas International Ltd., among others.

Key questions addressed by the report.

• What is the market growth rate?
• Which segment and region dominate the market in the base year?
• Which segment and region will project the fastest growth in the market?
• Who is the leader in the market?
• How are players addressing challenges to sustain growth?
• Where is the investment opportunity?

Global HFO Refrigerant Market Report Segment

By Refrigerant Type

• R-1234Yf
• R-1234Ze
• R-1234Zd

By Application

• Refrigeration
• Air-Conditioning

By End-User

• Domestic
• Commercial
• Transportation
• Industrial
• Others

Global HFO Refrigerant Market Report Segment by Region

North America

• United States
• Canada

Europe

• UK
• Germany
• Italy
• Spain
• France
• Russia
• Rest of Europe

Asia-Pacific

• China
• India
• Japan
• South Korea
• Australia and New Zealand
• ASEAN Economies
• Rest of Asia-Pacific

Rest of the World

• Latin America
• Middle East & Africa

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