Industry Overview

US oncology information system (OIS) market was valued at $1.3 billion in 2025 and is projected to reach $3.1 billion by 2035, registering a CAGR of 8.9% from 2026 to 2035. Oncology information systems are advanced healthcare IT platforms designed to manage patient data, optimize oncology workflows, and support clinical decision-making across medical, radiation, and surgical oncology. These systems integrate critical functions such as imaging, diagnostics, treatment planning, and patient monitoring, enabling healthcare providers to deliver accurate and personalized cancer care. Market growth is primarily driven by the rising incidence of cancer, increasing adoption of digital health technologies, and the growing need for efficient data management in oncology practices. Hospitals and specialized cancer centers are increasingly implementing OIS solutions to improve treatment precision, reduce administrative complexities, and enhance patient outcomes. Furthermore, advancements in artificial intelligence, cloud computing, and system interoperability are accelerating the adoption of these platforms across the country.

Technological innovations and strategic product developments are further strengthening the OIS landscape in the U.S. In January 2026, GE HealthCare received FDA 510(k) clearance for MIM LesionID Pro, an AI-enabled oncology imaging software that automates whole-body tumor burden analysis using PSMA PET/CT and SPECT/CT scans. This solution improves workflow efficiency by minimizing manual tumor segmentation and enabling accurate disease tracking for cancer patients. Similarly, in October 2024, Oracle introduced Oracle Analytics Intelligence for Life Sciences, an AI-powered, cloud-based platform that integrates healthcare and life sciences data. The platform supports oncology-focused teams by generating real-world insights for disease understanding, treatment optimization, and clinical decision-making. Such advancements are significantly enhancing the efficiency, data integration, and precision of oncology care delivery across the United States, contributing to the continued expansion of the OIS market.

Market Dynamicss

AI-Powered Software Revolutionizing U.S. Oncology Systems

Software segment leads the U.S. oncology information system market, driven by the growing adoption of integrated platforms for treatment planning, patient tracking, and clinical decision-making. These solutions enable seamless data exchange across imaging, diagnostics, and therapy systems, improving workflow efficiency. In April 2026, GE HealthCare secured U.S. FDA 510(k) clearance for True Definition DL, an advanced deep learning CT imaging software. The solution enhances spatial resolution and diagnostic accuracy, enabling clearer visualization of intricate anatomical structures. Such innovations are accelerating software-driven oncology adoption, supporting more precise diagnosis and optimized treatment planning.

AI-Powered Precision Fuels Radiation Oncology Growth

Radiation oncology is emerging as a rapidly expanding segment, driven by continuous advancements in therapy technologies and precision treatment approaches. In May 2024, GE HealthCare introduced AI-enabled personalized oncology solutions, including the Revolution RT system and enhanced Intelligent Radiation Therapy (iRT) platform. These innovations integrate advanced imaging and software capabilities to improve tumor targeting accuracy and streamline clinical workflows. They also support personalized, data-driven treatment planning, enhancing overall efficiency in oncology care. As a result, radiation oncology is playing a crucial role in improving patient outcomes while reducing treatment-related side effects.

Market Segmentation

• Based on product type, the market is segmented into software and services.
• Based on application, the market is segmented into medical oncology, radiation oncology, and surgical oncology.
• Based on end user, the market is segmented into hospitals, cancer treatment centers, and research & academic institutes.

Hospitals Drive Digital Oncology Revolution Through Strategic Partnerships

Hospitals continue to dominate the end-user segment, supported by advanced infrastructure, skilled professionals, and high patient volumes. Healthcare facilities are increasingly investing in oncology information systems to streamline workflows and enhance patient management. In April 2026, Siemens Healthineers entered a 10-year value partnership with Onvida Health to modernize diagnostic imaging and therapy infrastructure. The collaboration aims to boost clinical efficiency, integrate advanced technologies, and strengthen cancer care delivery. Such strategic initiatives are accelerating the adoption of integrated digital solutions across hospital-based oncology systems.

Market Players Outlook

The major companies operating in the US oncology information system market include McKesson Corporation, Siemens Healthineers, GE HealthCare, Philips Healthcare, and Oracle Health, among others. Market players are leveraging partnerships, collaborations, mergers, and acquisitions to expand their businesses and develop innovative products, maintaining their market positioning.

Recent Development

• In February 2026, Siemens Healthineersin a multi-year collaboration to advance cancer diagnostics and treatment in the US. The alliance focuses on integrating advanced imaging, digital technologies, and oncology workflows to enhance precision care and clinical efficiency. Such initiatives support the growth of oncology information systems by strengthening data integration and workflow optimization across hospital networks.

• In August 2025, Oracle introduced a next-generation AI-driven electronic health record (EHR) system designed to enhance clinical workflows and patient data management across US healthcare settings. The cloud-based platform integrates conversational AI and voice-enabled capabilities to improve care quality, reduce administrative burden, and support real-time clinical decision-making. Such advancements strengthen digital health infrastructure and support the adoption of oncology information systems by enabling more efficient cancer care management and data integration.

The Report Covers

• Market value data analysis of 2025 and forecast to 2035.
• Annualized market revenues ($ million) for each market segment.
• Key companies operating in the US oncology information system market
• Based on the availability of data, information related to new protections and relevant news is also available in the report.
• Analysis of business strategies by identifying the key market segments positioned for strong growth in the future.
• Analysis of market-entry and market expansion strategies.
• Competitive strategies by identifying ‘who-stands-where’ in the market.